Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Family Practice


Dr. Mary Walton



Post-traumatic stress disorder (PTSD) is a psychological condition that occurs in trauma victims, marked by intrusive memories, avoidance, negative changes in mood and thoughts, and changes in arousal and physical reactivity. PTSD is associated with an inferior quality of life and an increased risk of suicide. Many patients diagnosed with PTSD do not respond to frontline treatments. Recent studies have shown that Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy decreases symptoms and improves patient outcomes in refractory PTSD cases by eliminating fear and restabilizing memories. When prescribed in a controlled setting, the abuse potential is low. The results of MDMA-assisted psychotherapy were so groundbreaking that the Federal Drug Administration granted Breakthrough Therapy Designation for this promising treatment to expedite continued research and development.


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