Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Primary Care


Dr. Laura Witte


Whipple’s disease (WD) is a chronic infectious disease that is fatal if left untreated and may result in irreversible damage if treatment is delayed. A study published in 2019 suggests that WD is more prevalent than originally thought making improved awareness among clinicians of vital importance. Due to the high variability of presenting signs and symptoms, which may be encountered across multiple specialties, establishing the diagnosis can be challenging. While treatment is highly effective for inducing remission, recurrence is possible making long-term monitoring an essential part of the management plan. This article describes WD, its proposed pathophysiology, common presentations, methods of diagnosis, and recommendations for management.


Available when accessing via a campus IP address or logged in with a University of Lynchburg email address.

Off-campus users can also use 'Off-campus Download' button above for access.