University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Internal Medicine


Tom Colletti, DHSc, PA-C, DFAAPA


Buprenorphine-naloxone is effective at promoting opioid cessation when utilized as intended. However, contemporary research suggests buprenorphine-naloxone remains misused in the general population. Despite patient education, buprenorphine-naloxone is taken with depressants and often through improper routes to achieve unintended results. Supervision has been shown to reduce buprenorphine-naloxone misuse and diversion. Such supervision exists as an underexplored avenue to improve intervention efficacy. However, the literature assessing supervised buprenorphine-naloxone administration is scarce and requires further expansion to maximize the efficacy of this treatment strategy. Existing literature suggests a supervised approach would enhance current treatment paradigms. Further research is required to cement a correlation between diminished buprenorphine-naloxone diversion and medically supervised buprenorphine-naloxone administration in the outpatient setting.


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