University of Lynchburg DMSc Doctoral Project Assignment Repository
Specialty
Obstetrics and gynecology, neurology
Advisor
Laura Witte, PhD, PA-C
Abstract
Alzheimer’s disease is a devastating neurodegenerative condition that disproportionately affects women. With no known cure, many research studies have focused on preventative measures. Since estrogen facilitates cognitive function and declines during menopause, several studies have investigated a possible causal relationship between estrogen deficiency and the onset of Alzheimer’s disease. Many of the prior perceived risks of estrogen hormone therapy reported in the landmark Women’s Health Initiative study are now discredited if started early in menopause. When administered during this window of opportunity, estrogen hormone therapy could improve cognitive function and potentially prevent Alzheimer’s disease. Further research is needed to determine the adequate dose, route of administration, and optimal duration of treatment. The decision to initiate estrogen hormone therapy should be individualized for each patient after careful consideration of risks and benefits.
Recommended Citation
Hampton JM. Estrogen to Prevent Alzheimer's Disease: A Window of Opportunity. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2023; 5(1).
Restricted
Available when accessing via a campus IP address or logged in with a University of Lynchburg email address.
Off-campus users can also use 'Off-campus Download' button above for access.