Critical Care Medicine
Dysbiosis is the imbalance of gut intestinal microbiota most commonly caused by utilization of antibiotics. Dysbiosis in the critically ill patient occurs as a result of necessary treatments such as antibiotic administration. Subsequently, the imbalance in the normally protective bacteria leads to opportunist overgrowth of pathogens leading to secondary infections such as clostridium difficile (CDiff) and ventilator-associated pneumonias (VAP). Prophylactic and therapeutic utilization of probiotics decreases the occurrence of disruption of the gut microbiota which can further reduce incidence of these adverse effects. Additionally, reinstating and maintaining symbiosis has been demonstrated to reduce overall ICU mortality and length of stay. This article aims to portray the benefits and indications of probiotic treatment as well as address any contraindications in the adult ICU patient.
Erzen S. Utilization of Probiotics in the Adult ICU Patient. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2023; 5(2).
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