University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository




Dr. Victoria Beloy DMSc, PA-C


Traumatic brain injury (TBI) is an umbrella term representing all injuries that impact the function of the brain. In the United States (US), TBI accounts for approximately 220,000 hospitalizations and 64,000 deaths each year. Primary injury represents damage to the brain, which occurs at the time of the injury. Secondary injury represents additional brain damage resulting from the physiologic cascade initiated at the time of primary injury. One of the mainstay treatments for severe TBI patients is preventing further damage via secondary injury by using rapid diagnosis and intervention to avoid worsening neurological damage. Brain oxygenation (PbtO2) monitoring can be used as a marker to identify cerebral tissue at risk for secondary injury due to hypoxemia. Large, randomized control trials comparing neurological outcomes and overall mortality in adult patients with severe TBI monitored with PbtO2 are currently limited. However, available evidence suggests that monitoring patients with PbtO2, and managing cerebral hypoxemia, mildly improves neurological outcomes and mortality in adults with severe TBI by preventing additional damage via secondary injury.


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