The Impact of a Ketogenic- Style Diet on Lipid and Cholesterol Profiles

Authors

Casey L.S. Berrettini, University of LynchburgFollow

Specialty

Emergency Medicine

Advisor

Dr. Thomas Colletti

Abstract

The primary purpose of this research article is to establish whether a ketogenic style diet (KD) can mitigate hyperlipidemia (HLD), and as a result hypercholesterolemia, as an alternative to pharmacologic therapy. Pharmacologic therapy refers to statin medications, fenofibrate (fibric acid), and ezetimibe, an antilipemic agent. Google Scholar, PubMed, and MDPI Open Source were the primary search engines used, and filters included journals, articles, and books published within the past five years when possible. Of the resources reviewed, the primary outcomes indicated that short-term use of a KD had variable effects on total cholesterol, however caused an increase in low-density lipoprotein (LDL). A notable benefit to the KD was an overall improvement in metabolic health and decreased body mass index.

The bulk of the population used in the numerous studies reviewed consisted of individuals without comorbidities or cardiovascular disease, and the population sizes were small, thus limiting the applicability of the research. The results of this research imply that there is potential for a holistic, diet-based approach to managing and preventing hypercholesterolemia. Managing hypercholesterolemia with diet absent pharmacologic intervention lends to a healthier population, and less financial burden on patients and the healthcare system. Diet modification may facilitate overall improvement in health and encourage better nutritional and health education, potentiating improved preventative health practices. Further research should include larger population sizes, with a combined focus on metabolic improvements and improved overall health in relation to total cholesterol, high-density lipoprotein (HDL), and LDL. Further studies should also compare periods of KD and periods of statin therapy in the same patient population with both objective measurements and subjective results.

Recommended Citation

Berrettini CL. The Impact of a Ketogenic- Style Diet on Lipid and Cholesterol Profiles. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2025; 7(3).