Biostimulators as the Future of Aesthetic Medicine: Addressing the U.S. Lag Behind Europe and Asia

Authors

Jacqueline Luk, University of LynchburgFollow

Specialty

Aesthetic Medicine

Advisor

James Kilgore

Abstract

Aesthetic medicine in the United States is undergoing a gradual transformation from volume-based correction toward regenerative and skin-restorative therapies. Despite increasing demand for natural and enduring results, the U.S. continues to trail behind Europe and Asia in adopting biostimulatory injectables such as polydeoxyribonucleotides (PDRNs) and hybrid hyaluronic acid products, including Profhilo. These agents enhance collagen synthesis, promote dermal remodeling, and improve overall skin quality, producing results that extend beyond the temporary benefits of traditional fillers. However, domestic adoption remains limited due to regulatory hurdles, inadequate provider education, and a procedural culture centered on immediate correction through botulinum toxins and hyaluronic acid fillers.

This manuscript examines the clinical efficacy, safety, and aesthetic outcomes of biostimulatory injectables while comparing utilization patterns between the U.S. and international markets. Through a comprehensive literature review and environmental analysis, it identifies barriers to adoption and opportunities for physician associates (PAs) and other providers to advance regenerative aesthetic care. The analysis also explores scope-of-practice restrictions, litigation risks, and systemic biases within the U.S. aesthetic landscape. Findings suggest that biostimulators deliver superior longevity, patient satisfaction, and alignment with the global shift toward regenerative medicine. Advancing this field within the U.S. will require modernization of regulatory pathways, enhanced provider training, and interdisciplinary collaboration to ensure parity with international innovation in aesthetic medicine.

Recommended Citation

Luk J. Biostimulators as the Future of Aesthetic Medicine: Addressing the U.S. Lag Behind Europe and Asia. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2025; 7(3).