The Use of Psilocybin for Managing Refractory Behavioral Health Conditions: A New and Promising Approach

Authors

• Rachel N. Clark, University of LynchburgFollow

Specialty

Emergency Medicine

Advisor

Elochukwu Osoego

Abstract

The purpose of this review is to evaluate the possible benefits of using psilocybin(C₁₂H₁₇N₂O₄P), a naturally occurring psychoactive compound found in certain species of mushrooms, in the treatment of multiple forms of mental illness and substance abuse in either monotherapy or in conjunction with traditional psychiatric medications.  The compound acts as a high-affinity agonist for several serotonin receptors, including 5-HT_1A, 5-HT_2A, and 5-HT_2C, which are densely located throughout the cerebral cortex and thalamus. Following a comprehensive search of electronic databases, this review evaluates the pharmacokinetics, therapeutic efficacy, and safety profile of psilocybin in treating depression, anxiety, and addiction disorders.  The findings are promising and support its efficacy with decreased symptoms in multiple psychiatric disorders with a rapid onset.  Significant research barriers remain, including methodological limitations, regulatory constraints, and limited population diversity in clinical trials conducted to date. United States (US) federal funding for the study of psilocybin as a potential therapeutic option has not yet been approved.  Biosynthetic production of the compound and enhanced integration into psychotherapy are necessary to ensure scalability, safety, and accessibility. Future research is essential to evaluate and to refine its therapeutic applications on a larger scale.

Recommended Citation

Clark RN. The Use of Psilocybin for Managing Refractory Behavioral Health Conditions: A New and Promising Approach. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2026; 8(1).