Platelet-Rich Plasma Injections In Rotator Cuff Disease

Authors

• Lauren A. Seedlock, University of LynchburgFollow

Specialty

Orthopedic Surgery

Advisor

Dr. Thomas Colletti

Abstract

This study investigates the efficacy of platelet-rich plasma (PRP) injections for rotator cuff disease in improving pain and functional outcomes relative to current standard-of-care interventions. A detailed review of randomized controlled trials (RCTs) was conducted using the PubMed database. Clinical outcomes, specifically pain and shoulder function, were compared between patients receiving PRP and those receiving corticosteroid injections or undergoing surgical intervention. The findings indicate that PRP reduces pain and improves function when used as a first-line treatment.

While PRP appears particularly beneficial for patients with contraindications to corticosteroids or those unfit for surgery, significant variability in study designs and potential treatment biases underscore the need for standardized protocols. Future research involving long-term follow-up is essential to validate these outcomes and establish definitive clinical guidelines. This research can also guide the future of PRP injections for other orthopedic injuries.

Recommended Citation

Seedlock LA. Platelet-Rich Plasma Injections In Rotator Cuff Disease. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2026; 8(1).