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University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository

A Review of The Safety and Efficacy of Romiplostim for Thrombocytopenia Treatment In Allogeneic Hematopoietic Cell Transplantation

Specialty

Hematology and Oncology

Advisor

Dr. Debra Munsell

Abstract

ABSTRACT

The safety and efficacy of thrombopoietin receptor agonist romiplostim as treatment for thrombocytopenia after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and to enhance platelet recovery in patients undergoing umbilical cord blood transplantation (UCBT) were reviewed.  The findings suggest that romiplostim is effective and well-tolerated, and it also enhances platelet recovery in UCBT patients.  This review can help clinicians better understand the benefits of romiplostim and how to use it appropriately and promptly to improve the care of allo-HSCT patients with delayed platelet recovery or secondary failure of platelet recovery (SFPR) and to help UCBT patients achieve platelet recovery more quickly.

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