University of Lynchburg DMSc Doctoral Project Assignment Repository
Specialty
Orthopedics
Abstract
ABSTRACT
The global prevalence of knee osteoarthritis (OA) continues to increase with the societal impact evident in healthcare visits and associated costs. Knee OA is a complex, progressive disease involving synovial, cartilaginous, and bone alteration leading to narrowing of the tibiofemoral joint space via thinning of articular cartilage. Knee OA is characterized by knee pain and stiffening with patients often seeking treatment options that may decrease their pain and increase their function. Professional societies differ in their recommendations and proposed treatment algorithms for the management of knee OA pain and are particularly at odds concerning pharmacologic and procedural options. One procedural option which has recently emerged to treat painful knee OA is cryoneurolysis, a cold-based therapy targeting genicular nerves that innervate knee sensation. Multiple studies have evaluated the efficacy of cryoneurolysis for chronic knee OA pain as well as for pain control prior to total knee arthroplasty. This clinical review aims to explore the role of cryoneurolysis within the knee OA treatment algorithm.
Recommended Citation
Zeigler M. The Role of Cryoneurolysis in the Management of Knee Osteoarthritis Pain: From Initial Diagnosis to Definitive Treatment. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2026; 8(1).
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