A Clinical Review of Severe Malaria and Artemisinin Resistance in Sub-Saharan Africa

Authors

• Elizabeth R. Jones PA-C, University of LynchburgFollow

Abstract

This clinical review aims to examine the development of malaria resistance, the underlying genetic mutations in Plasmodium species, and the implications for managing severe malaria in resource-limited settings. Malaria remains a global health challenge, with the biggest burden in Sub-Saharan Africa, where hundreds of thousands of lives are lost each year to this preventable and treatable disease. Severe malaria, driven primarily by Plasmodium falciparum, accounts for the majority of these fatalities due to its severe complications. Artemisinin-based combination therapies are the cornerstone of malaria treatment worldwide. However, the emergence of artemisinin resistance in several Sub-Saharan African countries poses a significant threat to controlling the disease. We will discuss the life cycle of Plasmodium to provide context on how resistance develops and spreads. Understanding these mechanisms is crucial for adapting treatment protocols and developing new therapeutic strategies. By highlighting the importance of ongoing research and international collaboration, this review underscores the need for vigilance and innovation in the fight against malaria. Addressing artemisinin resistance is essential to reduce mortality and improve outcomes for the most affected populations. With a clear understanding of the challenges and a commitment to adaptive strategies, we can better safeguard vulnerable communities and make strides toward malaria control and elimination.

Recommended Citation

Jones ER. A Clinical Review of Severe Malaria and Artemisinin Resistance in Sub-Saharan Africa. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2026; 8(1).