Poster or Presentation Title

Analysis of the Effects of the Protein Survivin on Histone H3 in Metastatic Breast Cancer

Student Author Information

Emma Strouse, University of LynchburgFollow

Location

Virtual | Room 4

Access Type

Campus Access Only

Presentation Type

Oral Presentation

Start Date

7-4-2021 2:15 PM

End Date

7-4-2021 2:30 PM

Department

Biomedical Science

Abstract

In normally functioning cell lines, the protein survivin remains at consistently low levels at all times. However, in cancerous cells, it is known that survivin is produced and remains at considerably high levels, especially in breast cancer cells. This gives clear indication that the protein is highly correlated with cancer progression, so it could also become an important biomarker for cancer development. However, the specifics about the molecular interactions that survivin participates in, as well as the purpose of its overproduction in a cancerous cell, are largely unknown. Survivin has two functions: its predominant role as an IAP (inhibitor of apoptosis protein) and its role in mediating the cell cycle. It is hypothesized that survivin likely remains at high levels in cancerous tissue so that the cell can ignore signals for apoptosis. The predominant focus of this study is survivins’ interaction with histone H3 and their effect on apoptotic conditions. The interaction of survivin and histone H3 could be very important for not only cancer development but also the prognosis, diagnosis, and treatment of breast cancer. The results of this research lead to the discovery of potential target pathways for therapeutic drugs.

Faculty Mentor(s)

Dr. Allison B Jablonski
Dr. Erin Friedman
Dr. Jennifer Styrsky

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Apr 7th, 2:15 PM Apr 7th, 2:30 PM

Analysis of the Effects of the Protein Survivin on Histone H3 in Metastatic Breast Cancer

Virtual | Room 4

In normally functioning cell lines, the protein survivin remains at consistently low levels at all times. However, in cancerous cells, it is known that survivin is produced and remains at considerably high levels, especially in breast cancer cells. This gives clear indication that the protein is highly correlated with cancer progression, so it could also become an important biomarker for cancer development. However, the specifics about the molecular interactions that survivin participates in, as well as the purpose of its overproduction in a cancerous cell, are largely unknown. Survivin has two functions: its predominant role as an IAP (inhibitor of apoptosis protein) and its role in mediating the cell cycle. It is hypothesized that survivin likely remains at high levels in cancerous tissue so that the cell can ignore signals for apoptosis. The predominant focus of this study is survivins’ interaction with histone H3 and their effect on apoptotic conditions. The interaction of survivin and histone H3 could be very important for not only cancer development but also the prognosis, diagnosis, and treatment of breast cancer. The results of this research lead to the discovery of potential target pathways for therapeutic drugs.