Bachelor of Science
Aspernigrin A is a compound correlated with inhibiting the growth of cancer cells in the colon. A five-step synthesis was designated for aspernigrin A, projected to yield four intermediates and the final product. The intermediates were analyzed by high field H-NMR and FT-IR spectroscopy before proceeding to the next step. A model pyridone ring system was successfully prepared from a commercially available pyrone precursor in two steps. These results provide a proof of concept that the synthetic scheme should successfully yield the natural product.
Joerger, Erica, "Synthesisof Aspernigrin A" (2006). Undergraduate Theses and Capstone Projects. 3.