Author ORCID Identifier(s)
0009-0001-0589-6761
Abstract
This case snippet describes the diagnostic journey and clinical management of a 72-year-old gentleman who presented with progressive cognitive decline, involuntary myoclonus, and severe insomnia. Through a detailed clinical workup, including electromyography and antibody testing, he was diagnosed with Contactin-Associated Protein-Like 2 (CASPR2) antibody-associated autoimmune encephalitis manifesting as Morvan’s syndrome, a rare but reversible neuroimmunological disorder. Prompt initiation of immunotherapy led to gradual improvement, underscoring the value of clinical suspicion, multidisciplinary care, and early intervention. This case serves as a reminder to consider autoimmune etiologies in atypical neuropsychiatric presentations, especially in elderly patients.
Recommended Citation
M, Yashfeen
(2025)
"A Twisting Trail to Diagnosis: Unraveling Morvan’s Syndrome in CASPR2-Associated Autoimmune Encephalitis,"
Journal Of Indian Physician Associates: Vol. 1:
Iss.
1, Article 7.
Available at:
https://digitalshowcase.lynchburg.edu/jipa/vol1/iss1/7