Oral Presentations
Location
Room 232, Schewel Hall
Access Type
Open Access
Entry Number
59
Start Date
4-10-2019 2:00 PM
End Date
4-10-2019 2:15 PM
College
Lynchburg College of Arts and Sciences
Department
Biomedical Science
Abstract
The second most common cancer in men is prostate cancer. Prostate cancer is traditionally diagnosed by a digital rectal exam. Blood tests can also be used to test for PSA (prostate-specific antigen). These two methods can be used together but can sometimes provide both false negative and false positive results. A new method of testing for prostate cancer could prove to be beneficial. Previous studies have shown that active HERV sequences have been identified in some cancers, including prostate cancer. We hypothesize that the presence of active HERV in prostate cancer lines is significant. In this study, rabbit polyclonal antibodies and Western blotting were used to assay for the presence of HERV protein products after 5-aza-2’-deoxycytidine was used to amplify transcripts of prostate cancer-specific genes. Positive results may suggest a new method to detect prostate cancer in patient samples.
Faculty Mentor(s)
Dr. Allison Jablonski
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Included in
Exploration of Prostate Cancer Cells: The Significance of Active HERV
Room 232, Schewel Hall
The second most common cancer in men is prostate cancer. Prostate cancer is traditionally diagnosed by a digital rectal exam. Blood tests can also be used to test for PSA (prostate-specific antigen). These two methods can be used together but can sometimes provide both false negative and false positive results. A new method of testing for prostate cancer could prove to be beneficial. Previous studies have shown that active HERV sequences have been identified in some cancers, including prostate cancer. We hypothesize that the presence of active HERV in prostate cancer lines is significant. In this study, rabbit polyclonal antibodies and Western blotting were used to assay for the presence of HERV protein products after 5-aza-2’-deoxycytidine was used to amplify transcripts of prostate cancer-specific genes. Positive results may suggest a new method to detect prostate cancer in patient samples.