Date Presented

Spring 4-2006

Document Type

Thesis

Access Type

1

Degree Name

Bachelor of Science

Department

Chemistry

First Advisor

Dr. Anne Reeve

Second Advisor

Dr. Priscilla Gannicott

Third Advisor

Dr. Nancy Cowden

Abstract

Aspernigrin A is a compound correlated with inhibiting the growth of cancer cells in the colon. A five-step synthesis was designed for aspernigrin A, projected to yield four intermediates and the final product. The intermediates were analyzed by high field 1HNMR and FT-IR spectroscopy before proceeding to the next step. A model pyridone ring system was successfully prepared from a commercially available pyrone precursor in two steps. These results provide a proof of concept that the synthetic scheme should successfully yield the natural product.

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