Bachelor of Science
Dr. Anne Reeve
Dr. Priscilla Gannicott
Dr. Nancy Cowden
Aspernigrin A is a compound correlated with inhibiting the growth of cancer cells in the colon. A five-step synthesis was designed for aspernigrin A, projected to yield four intermediates and the final product. The intermediates were analyzed by high field 1HNMR and FT-IR spectroscopy before proceeding to the next step. A model pyridone ring system was successfully prepared from a commercially available pyrone precursor in two steps. These results provide a proof of concept that the synthetic scheme should successfully yield the natural product.
Joerger, Erica, "Synthesis of Aspernigrin A" (2006). Undergraduate Theses and Capstone Projects. 64.