COVID-19 POTS
Location
Hopwood Auditorium
Access Type
Campus Access Only
Entry Number
124
Start Date
4-5-2023 4:30 PM
End Date
4-5-2023 4:45 PM
College
College of Medical Sciences
Department
Physician Assistant
Keywords
COVID-19, Postural Orthostatic Tachycardia Syndrome
Abstract
Postural orthostatic tachycardia syndrome (POTS) is a common condition marked by autonomic dysfunction. POTS’ pathophysiology is multifactorial and its symptoms include presyncope, heart palpitations, lightheadedness, blurred vision, and syncope. A few possible causes of POTS include trauma, pregnancy, and most importantly, post-infection. Common infections known to trigger POTS include EBV, influenza, and the newly discovered COVID-19. Due to the high transmission rate of COVID-19, POTS has been more heavily diagnosed within the past couple of years. Different theories of why POTS occurs include a lower than normal amount of blood volume, an inability to quickly vasoconstrict blood vessels, and an elevated amount of norepinephrine. COVID-19 is suspected to trigger POTS due to a possible relationship in the downregulation of the RAAS system as the COVID-19 spike protein has been found to bind to ACE inhibitors. This paper focuses on the pathophysiology of POTS and orthostatic intolerance as well as diagnosis and management and the relationship between COVID-19 and POTS and what the timeline for those diseases can look like as well as prognosis and focus for future research. Future research studies are working to develop target therapies for COVID-19 POTS. Although POTS is a chronic condition, it is not associated with high mortality but high morbidity. Furthermore, barriers such as lack of knowledge of providers make it difficult to determine the prognosis.
Faculty Mentor(s)
Dr. Jenna Rolfs Dr. Eric Schmidt
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COVID-19 POTS
Hopwood Auditorium
Postural orthostatic tachycardia syndrome (POTS) is a common condition marked by autonomic dysfunction. POTS’ pathophysiology is multifactorial and its symptoms include presyncope, heart palpitations, lightheadedness, blurred vision, and syncope. A few possible causes of POTS include trauma, pregnancy, and most importantly, post-infection. Common infections known to trigger POTS include EBV, influenza, and the newly discovered COVID-19. Due to the high transmission rate of COVID-19, POTS has been more heavily diagnosed within the past couple of years. Different theories of why POTS occurs include a lower than normal amount of blood volume, an inability to quickly vasoconstrict blood vessels, and an elevated amount of norepinephrine. COVID-19 is suspected to trigger POTS due to a possible relationship in the downregulation of the RAAS system as the COVID-19 spike protein has been found to bind to ACE inhibitors. This paper focuses on the pathophysiology of POTS and orthostatic intolerance as well as diagnosis and management and the relationship between COVID-19 and POTS and what the timeline for those diseases can look like as well as prognosis and focus for future research. Future research studies are working to develop target therapies for COVID-19 POTS. Although POTS is a chronic condition, it is not associated with high mortality but high morbidity. Furthermore, barriers such as lack of knowledge of providers make it difficult to determine the prognosis.